解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Highly cross-linked networks formed by the photoinitiated polymerization of multifunctional monomers are finding application in the field of biomaterials because of their chemical versatility, reaction control, and ability to polymerize under physiological conditions. Typically, degradation is introduced into these ne...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025677o
更新日期:2003-01-01 00:00:00
abstract::The microstructure and the rheological properties of pure HM (high methoxyl) and LM (low methoxyl) pectin gels and of mixed HM/LM pectin gels have been investigated. Gel formation of either the HM or LM pectin, or both, was initiated in the mixed gels by varying the sucrose and Ca(2+) content. The microstructure was c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020044v
更新日期:2002-11-01 00:00:00
abstract::Electrospinning for the formation of nanoscale diameter fibers has been explored for high-performance filters and biomaterial scaffolds for vascular grafts or wound dressings. Fibers with nanoscale diameters provide benefits due to high surface area. In the present study we explore electrospinning for protein-based bi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025581u
更新日期:2002-11-01 00:00:00
abstract::Amino groups were covalently introduced onto a polycaprolactone (PCL) surface by the reaction between 1,6-hexanediamine and the ester groups of PCL. The occurrence of the aminolysis and the introduction of free NH(2) groups were verified qualitatively by fluorescence spectroscopy, where rhodamine B isothiocyanate was ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020074y
更新日期:2002-11-01 00:00:00
abstract::New types of hydrogels have been obtained starting from high bloom purified gelatin A, alone or in mixtures with hyaluronan and with a hyaluronan derivative bearing primary amino groups, by transglutaminase-catalyzed cross-linking. The reticulation process, carried out adopting two different temperature protocols, and...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025657m
更新日期:2002-11-01 00:00:00
abstract::Poly(L-lactide)-based microspheres having cationic or anionic surfaces were prepared using polydepsipeptide-block-poly(L-lactide)s as surfactants. Polydepsipeptide-block-poly(L-lactide)s having amino or carboxylic acid groups on their side chains were synthesized through anionic ring-opening polymerizations of L-lacti...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0200231
更新日期:2002-09-01 00:00:00
abstract::In the present study we describe the synthesis, wet spinning, mechanical testing, and degradation of poly(urethane urea)s (PUURs) intended for clinical use in anterior cruciate ligament (ACL) reconstruction. The effects of soft segment chemical composition and molar mass and the kind of diamine chain extender on the m...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025535u
更新日期:2002-09-01 00:00:00
abstract::We synthesized positively charged biodegradable hydrogels by cross-linking of agmatine-modified poly(ethylene glycol)-tethered fumarate (Agm-PEGF) and poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) to investigate the effect of the guanidino groups of the agmatine on hydrogel swelling behavior and smooth mus...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0200433
更新日期:2002-09-01 00:00:00
abstract::A porous scaffold as a cell-compatible material was designed and prepared using a phospholipid copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate, and enantiomeric macromonomers, the poly(L-lactic acid) (PLLA) macromonomer, and poly(D-lactic acid) (PDLA) macromonomer. On the bas...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025586r
更新日期:2002-09-01 00:00:00
abstract::Phase separation mechanisms and kinetics were studied using small-angle light scattering in a gelatin/maltodextrin system where phase separation could be studied in both liquid and gelled states. Nucleation and growth or spinodal decomposition occurred, depending on the quench depth. The transition between the two mec...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025501m
更新日期:2002-07-01 00:00:00
abstract::Following the work carried out on guar gum in our first paper of a series, the "pressure cell" solubilization method was applied to two other less highly substituted galactomannans: locust bean gum (LBG) and tara gum. True molecular solution of the polymers was achieved using appropriate temperature, time, and pressur...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025517c
更新日期:2002-07-01 00:00:00
abstract::Copolymers of (R)-3-hydroxybutyric acid (HB) and epsilon-caprolactone (CL) with a composition ranging from 28 to 81 mol % of HB were synthesized by transesterification of the corresponding homopolymers in solution in the presence of 4-toluenesulfonic acid. The copolyesters were characterized with regard to their molec...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025525t
更新日期:2002-07-01 00:00:00
abstract::A His-tagged coiled coil stem loop peptide with stable secondary structure was designed and biosynthesized. A series of oligopeptides related to the EBV envelope glycoprotein 350/220 N-terminal nonapeptide as potential CD21 receptor-binding epitopes were engineered into the loop region of the peptide scaffold. It was ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015606+
更新日期:2002-05-01 00:00:00
abstract::The synergistic interaction between xanthan and glucomannan in solution and in the gel phase has been studied by circular dichroism spectroscopy and differential scanning calorimetry. The study in solution of the polysaccharidic mixture indicates a preferred stoichiometry of the interaction corresponding to a weight f...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010163v
更新日期:2002-05-01 00:00:00
abstract::The structure of three types of liposomes (egg yolk phosphatidylcholine (EPC) without modification and EPC vesicles containing cross-linked N-isopropylacrylamide (NIPAM) networks of low and a high concentration inside the vesicles) were analyzed by static and dynamic light scattering. Upon polymerization the network w...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0200074
更新日期:2002-05-01 00:00:00
abstract::A N,N-dimethylacrylamide-based hydrogel (2) with the new cross-linker (ethylenedioxy) bis[2,2'-(N-acryloylamino)ethane] (1) has been prepared, and its physicochemical properties in aqueous solution were studied. Three different native proteins (lysozyme, bovine serum albumin, and rabbit IgG) were encapsulated within t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010147y
更新日期:2002-03-01 00:00:00
abstract::The Bacillus subtilis protease Proleather FG-F catalyzed the transesterification of inulin with vinyl acrylate (VA) in dimethylformamide (DMF). The reaction conversion for different VA concentrations was greater than 57% after 96 h at 50 degrees C. The degree of substitution (DS, defined as the amount of acrylate grou...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010150h
更新日期:2002-03-01 00:00:00
abstract::The morphology of silk produced by recluse spiders (Loxosceles arizonica) was investigated by scanning electron microscopy, atomic force microscopy, and transmission electron microscopy. This silk consisted entirely of very long, thin ribbons of width 2-4 microm and thicknesses of no more than 40 nm. The correspondenc...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010108m
更新日期:2002-01-01 00:00:00
abstract::By monitoring the thermally driven displacements of imbedded polystyrene microspheres via video fluorescence microscopy, we quantified the microstructural and micromechanical heterogeneities of wheat gliadin suspensions. We found that the degree of heterogeneity of the suspensions, as measured by the width and skewnes...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015586b
更新日期:2002-01-01 00:00:00
abstract::The synthesis and polymerization of six AB(3) tapered self-assembling methacrylate monomers (5a, 5b, 5c,5d, 17a, and 17b) based on first generation alkyl substituted benzyl ether monodendrons (i.e., minidendrons) containing oligooxyethylene units at their focal point and the polymerizable group on their periphery are ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010138p
更新日期:2002-01-01 00:00:00
abstract::Poly(beta-hydroxybutyrate) (PHB) modified with different amounts of pentaerythritol ethoxylate (PEE) has been synthesized using Ralstonia eutropha. The growth kinetics and the synthesis of PHB in the presence of PEE were modeled using appropriate differential equations for the mass balance of the two-stage process. Th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010088o
更新日期:2001-10-01 00:00:00
abstract::Small-angle X-ray scattering (SAXS) experiments with in situ dehydration have been performed on small bundles of flax fibers. Analysis indicated that the structure of the cellulose microfibrils is consistent with a cross section of approximately 10 x 50 A2. The microfibril misalignment was Gaussian with a full width a...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm005643l
更新日期:2001-10-01 00:00:00
abstract::A series of chitosan/chitin samples with DA's varying between 5.2 and 89% was prepared from the reacetylation under soft conditions of a unique chitosan sample allowing the preservation of the chain distribution. The study of the variation of pH for the same concentration of amine groups, at different ionic strengths,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015531+
更新日期:2001-10-01 00:00:00
abstract::Neutron reflectometry was used to investigate the time-dependent beta-casein adsorption at the silica-aqueous solution interface. The transient and steady-state structural characteristics of the adsorbed layer were determined from reflectivity curves, fitted to three-layer and two-layer models. The results show that t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0155221
更新日期:2001-10-01 00:00:00
abstract::Decomposable hollow capsules based on deoxyribonucleic acid (DNA) and a low molecular weight organic molecule, a naturally occurring polyamine, spermidine (SP), were formed by applying the layer-by-layer adsorption strategy to colloid particles, viz., assembling DNA/SP multilayers on colloids and subsequently removing...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010052w
更新日期:2001-10-01 00:00:00
abstract::Two kinds of regioselectively substituted cellulose derivatives, i.e., 6-O-triphenylmethylcellulose (6TC) and 2,3-di-O-acetyl-6-O-triphenylmethylcellulose (2,3Ac6TC), were prepared via cellulose. In these samples, C-6 position hydroxyls in the anhydroglucose units (AGU) along the cellulose chain were selectively subst...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010069e
更新日期:2001-10-01 00:00:00
abstract::Although composed simply of glucose polymers, the starch granule is a complex, semicrystalline structure. Much of this complexity arises from the fact that the two primary enzymes of synthesis-starch synthase and starch-branching enzyme-exist as multiple isoforms. Each form has distinct properties and plays a unique r...
journal_title:Biomacromolecules
pub_type: 杂志文章,评审
doi:10.1021/bm000133c
更新日期:2001-07-01 00:00:00
abstract::A revised crystal structure for mercerized cellulose based on high-resolution synchrotron X-ray data collected from ramie fibers is reported (space group P2(1), a = 8.10(3) A, b = 9.03(3) A, c = 10.31(5) A, gamma = 117.10(5) degrees; 751 reflections in 304 composite spots; theta < 21.11 degrees; lambda = 0.7208 A; LAL...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm005612q
更新日期:2001-07-01 00:00:00
abstract::The aggregation phenomena in aqueous solutions of hydrophobically modified (HM) chitosan, containing 4 mol % of n-dodecyl side chains, were studied by viscometry and fluorescence spectroscopy with pyrene as a probe. The results are compared with those for unmodified chitosan. Surprisingly, fluorescence data reveal the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm005649a
更新日期:2001-07-01 00:00:00
abstract::The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the u...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0155120
更新日期:2001-07-01 00:00:00
abstract::Enzymatic adsorption and degradation of three types of aliphatic polyester films and two types of polyolefin films by the extracellular PHB depolymerase from Alcaligenes faecalis T1 have been studied by using a quartz crystal microbalance (QCM) technique. Hydrolysis of poly[(R)-3-hydroxybutyrate] was quantitatively fo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0000844
更新日期:2001-04-01 00:00:00
abstract::The importance of the stabilization of the quaternary structure of multimeric enzymes has been illustrated using a model reaction with great industrial relevance: the enzymatic synthesis of ampicillin from 6-amino penicillanic acid (6APA) and phenylglycine methyl ester (PGM) catalyzed by the tetrameric enzyme alpha-am...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm000072i
更新日期:2001-04-01 00:00:00
abstract::A new mathematical model is presented for the analysis of the substituent distribution in the polymer chain of polysaccharide derivatives. For the first time, the influence of substitution on the reactivity of neighbored monomer units is taken into account. The model was applied to various cellulose and amylose ethers...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm000093c
更新日期:2001-04-01 00:00:00
abstract::Recombinant Escherichia coli strains harboring a plasmid containing a novel artificial polyhydroxyalkanoate (PHA) operon consisting of the Aeromonas PHA biosynthesis related genes and Ralstonia eutropha reductase gene were developed for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) [P(3HB-co-3HHx)] fro...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm000105u
更新日期:2001-04-01 00:00:00
abstract::The manufacture of biodegradable materials from agricultural sources is a real challenge, because of environmental concerns and the need to make full use of resources. Cottonseed is an important protein source that could be used in nonfood applications, as a substitute for synthetic polymers. For the first time, the v...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015525d
更新日期:2001-01-01 00:00:00
abstract::The antiproliferative activity of alkylated heparin, in which the terminal end of heparin is derivatized with an alkyl group (butyl, octyl, lauryl, stearyl), was examined using vascular smooth muscle cells. The proliferation of cells, which were growth-arrested prior to addition of heparin, was inhibited in proportion...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010097x
更新日期:2001-01-01 00:00:00
abstract::Inulin, the polydisperse reserve polysaccharide from chicory, has been modified by carbamoylation in organic solvents. The reaction of inulin with a range of alkyl isocyanates resulted, after crystalization, in a variety of carbamoylated inulins from which the interfacial properties were determined. The medium and lon...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015570l
更新日期:2001-01-01 00:00:00
abstract::Native cellulose consists of a set of parallel chains composed of glucose. Most of the time, these chains are highly ordered and form a structure that is known as a microfibril. On the other hand, highly crystalline forms of cellulose are more difficult to process and often are unpredictable in their behavior. If an o...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0101318
更新日期:2001-01-01 00:00:00
abstract::Aggregation phenomena in aqueous solutions of purified human tracheobronchial mucin have been studied by rheological methods, steady-state fluorescence, quasielastic light scattering, and spin probe techniques. At temperatures below 30 degrees C and concentrations above 15 mg/mL and in the absence of chaotropic agents...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm005532m
更新日期:2000-10-01 00:00:00
abstract::Effects of molecular weight (Lc) and field strength (E) on conformation of polymer chains and their density are investigated at the surface and bulk of a driven chain system in three dimensions with a Monte Carlo simulation. As the polymer chains deposit on the surface, a linear density gradient develops in low field....
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm000289c
更新日期:2000-10-01 00:00:00